There's a Big Family Hiding in Your Body

Cytokines

Cytokines are proteins that act as messengers in the immune system, which protects the body from threats like germs. The immune system contains cells that fight pathogens, allergens, and harmful substances. Cytokines signal these cells to combat invaders and maintain immune function even without threats.

Cytokine detection - very necessary

Dynamic monitoring of cytokine levels in the course of disease development can detect the tendency of the disease to deteriorate in a timely manner, so that timely treatment can be carried out to avoid or reduce the risk of deterioration of the disease, realizing the goal of "treating the disease before it gets worse", and increasing the effectiveness of clinical treatment.

Clinical significance of cytokine co-tests

To assist in the diagnosis of early infections and guide treatment in a timely manner to avoid deterioration of the condition; to assess the efficacy of medication at an earlier stage to avoid over-treatment.

Early warning of cytokine storm, timely treatment, and improved survival rate of critically ill patients

Cytokine storm can be caused by sepsis, severe infections, phagocytic syndrome, tumor immunotherapy, fever pending investigation, rare variant viral infections, or patients undergoing major surgery. Monitoring cytokines and treating them promptly can improve survival in critically ill patients.

Evaluate the body's inflammatory and immune status (SIRS/CARS/MARS) to provide precise treatment

Critically ill patients may have three inflammatory/immune states: SIRS (Systemic Inflammatory Response Syndrome), CARS (Antagonistic Inflammatory Response Syndrome), and MARS (Mixed Antagonistic Response Syndrome). Monitoring cytokine levels in critically ill patients can help to differentiate immune/inflammatory states and provide precise treatment.

Diagnosis of early infection

IL-1β， IL-6, IL-8, and TNF-α are pro-inflammatory markers elevated in common infections; IFN-γ is key in viral infections. Compared to traditional markers like WBC, CRP, and PCT, cytokines provide an earlier diagnostic window, aiding in early infection detection and treatment guidance, thus enhancing therapeutic effectiveness. Additionally, cytokines have a shorter half-life, making them more suitable for monitoring treatment efficacy in infected patients.

Early warning of the risk of miscarriage and pre-eclampsia

Normal pregnancy requires immune recognition of fetal antigens of paternal origin by the maternal immune system and the development of immune tolerance. A dysregulation of the immune tolerance microenvironment can lead to miscarriage. Therefore, cytokine testing can be used to assess the risk of miscarriage in pregnant women and the efficacy of clinical treatments in selected infertility patients.

Cytokines and tumor

Evaluate tumor microenvironment progression and assist in early tumor diagnosis. If IL-6, IL-10, IL-12 are mildly elevated and IL-2, TNF-α, IFN-γ are significantly decreased, it suggests that there may be early tumor microenvironment progression. Early warning of cytokine release syndrome (CRS), an adverse reaction to PD-1 therapy/CAR-T therapy.

Getein's Solution

Cytokines have long been widely used in the field of critical care, and the number of products for timely cytokine detection has gradually increased. With the advancement of testing technology, Getein chemiluminescent Cytokines 6 items, the first to realize rapid automated testing. There are also other cardiac, inflammation, thyroid function, tumor marker, hormone and other items for you to choose. Getein Chemiluminescence Immunoassay Analyzer Solution protects the health of the suitable test population! We are always pursuing the maximization of customer satisfaction, and continue to provide fast, professional and efficient services to our global customers.

Reference

1.Hughes CE, Nibbs RJB. A guide to chemokines and their receptors (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120486/). FEBS J. 2018;285(16):2944-2971. Accessed 1/3/2023.

2.Justiz Vaillant AA, Qurie A. Interleukin (https://www.ncbi.nlm.nih.gov/books/NBK499840/). 2022 Aug 22. In: StatPearls [Internet]. Treasure Island, FL: StatPearls Publishing; 2022 Jan-. Accessed 1/3/2023.

3.Khanna NR, Gerriets V. Interferon (https://www.ncbi.nlm.nih.gov/books/NBK555932/?report=reader). 2022 Jul 12. In: StatPearls [Internet]. Treasure Island, FL: StatPearls Publishing; 2022 Jan-. Accessed 1/3/2023.